Dissolution Sampling Robot
Dissolution Sampling Robot - DSR-M
The PharmaTest DSR-M dissolution sampling robot is designed specifically for the sample collection and sample processing from a 6, 8 or 12 vessel dissolution baths. This versatile instrument allows samples to be collected very quickly as fast as every 2 minutes. The DSR-M can also be equipped to collect, dilute or process samples for subsequent UV or HPLC analysis It can also be used for dissolution medium replacement for sample volume withdrawn loss.
A Powerful Solution to Automated Sampling
Up to twenty sampling cycles can be run automatically. The sample preparation station, Z-arm and needle, can be used to dispense into Septa sealed HPLC vials or dilute samples. Keeping the samples in sealed vials helps to avoid evaporation. The DSR-M is equipped with two collection racks. Each rack has the capacity to store up to ten sampling cycles. In the case of sample processing, such as dilution, the first rack is used for collecting and the second rack for sample dilutions. The innovative rack design makes it possible to use the same racks for standard open vials as well as for septa sealed HPLC vials. Flip the rack over, and its now ready for sample test tubes. The DSR-M is contained in a clear view Plexiglas enclosure. After the sampling is completed, the rack can easily be pulled out and removed to transport the samples for analysis.
Next Generation Technology
The DSR-M is the first such system to be equipped with high precision valve-free piston pumps. Each channel contains a miniaturized valve-free pump element which ensures reliable precision (<0.5%) and accurate sample delivery (<1%) for each working channel. No time consuming pump calibration is needed. The advanced design of the system means that it is always ready for operation and as the pump is already built-in the system saving a lot of bench space. The separate rinse pump is invaluable to keep the system clear of crystallizing material, especially when using buffered media.
In Line Filtering
lf filtration beyond the cannula filters on the sampling manifold is required, we offer the MFC-12 manual filter changer. With this filter changer it is possible to conveniently exchange a syringe filter for up to 12 channels in the dissolution system. The MFC-12 is installed into the tubing system of the dissolution system and can quickly be opened using the two open and close handles. When the MFC-12 is opened, the filters are automatically disconnected and can be removed quickly. New filters can then be inserted and are automatically locked into the tubing connectors, when the MFC-12 is closed again. Since these syringe filters can pass liquid only in one direction, a bypass is needed to use the MFC-12 in a DSR-M system with CAT-M piston pumps. For this we offer the DSR-MSV valve station in multiple models according the number of channels in the automated dissolution system.
All necessary sample handling information, such as dilution factor, sample transfer into empty septa closed vials is directly entered at the DSR-M using the integrated keypad. The programming is displayed clearly on the back lit LCD screen. Alternatively, the DSR-M can be controlled by a connected Pharma Test dissolution testing instrument. No additional PC software is required to use the DSR-M. A trigger signal starts the DSR-M sampling pumps so that the preset volume is withdrawn and dispensed into the vials or tubes which are in the sample racks. Only one sample line is required from the dissolution testing instrument via the sampling manifold since all liquid sampling and refilling is made through the same tubing. So no need for extra return tubing for refilling and automated tube flushing previous to the consequent sampling interval.
- Integrated valve-free piston pumps for high precision collection
- Modular design to allow auto media refill, dilution and transfer into sealed vials for six to twelve station dissolution baths
- Up to 20 sampling cycles (10 cycles with dilution)
- Less than 1% transfer error
- Automated media replacement with CAT-MRM module without the need of separate refilling tubing lines (option)
- Supports 0.45 micron filtration using MFC-12 manual filter changer and DSR-MVS valve station
- Sampling sequences are programmed direcly at the Pharma Test dissolution bath
- Stand-alone mode available to support third party dissolution bath